Why the study?
Does sympathetic activation induced by a low-salt diet increase sensitivity to quinidine-induced QT prolongation in normal volunteers?
Population
Normal volunteers
Comparison
Quinidine administration during a low-salt diet… vs Quinidine administration during a high-salt…
Design
Other
Follow-up
8 days per diet phase
Authors
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May heighten quinidine QT sensitivity during low-salt intake; hypothesis-generating for sympathetic effects, pending patient studies.
Does sympathetic activation induced by a low-salt diet increase sensitivity to quinidine-induced QT prolongation in normal volunteers?
Sympathetic activation from a low-salt diet increases sensitivity to quinidine-induced QT prolongation, an effect that can be reversed by beta blockade.
Darbar et al. (2001) studied this question.
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