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Litter susceptibility variation may affect Coxsackie isolation reliability; leaves open optimal animal numbers for diagnostic assays.
SummaryData are presented which suggest differences in susceptibility of different litters of suckling mice used for the primary isolation of Coxsackie viruses. It is suggested that at least 2 litters including a total of 12 to 15 suckling mice be used for demonstrating Coxsackie viruses in clinical specimens.
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Sulkin et al. (1951) studied this question.
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