Key result
BALB/c mice were most susceptible to group B coxsackievirus serotypes 1 to 6, whereas C3H mice were resistant, indicating host genetic background determines viral susceptibility.
The genetic background of the host significantly affects susceptibility to group B coxsackieviruses, with BALB/c mice being the most suitable for clinical isolation.
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Guides mouse strain selection for coxsackievirus isolation studies; leaves open translation of host genetic effects to human susceptibility.
Laboratory strains of group B coxsackievirus serotypes 1 to 6 were inoculated intraperitoneally into newborn mice of differing genetic backgrouns. Of the four genetic strains investigated, C3H mice appeared to be resistant to all six serotypes, whereas BALB/c mice were most susceptible. Swiss mice and a random-bred Swiss strain (COH) were intermediate in susceptibility. The findings underscore the fact that clinical isolation attempts and experimental studies involving group B coxsackieviruses must take into account both the virus strain used and the genetic background of the host. For clinical isolation of these viruses, the BALB/c mouse may be the most suitable of th strains tested.
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Minnich et al. (1980) studied Group B coxsackievirus infections. Intraperitoneal inoculation of group B coxsackievirus serotypes 1 to 6 vs. Differing genetic backgrounds was evaluated on Susceptibility to group B coxsackievirus. BALB/c mice were most susceptible to group B coxsackievirus serotypes 1 to 6, whereas C3H mice were resistant, indicating host genetic background determines viral susceptibility.
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