Key result
Germ-free Swiss albino mice were significantly less susceptible to Coxsackie B-1 virus infection than their conventional counterparts, while sex was not a determinant of susceptibility.
Germ-free mice are less susceptible to Coxsackie B-1 virus infection than conventional mice, highlighting the potential role of the microbiome or environmental exposure in viral susceptibility.
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Does not support microbiome interventions for human viral infections; leaves open the role of microbial exposure in susceptibility.
A distinct difference exists in the susceptibility of different strains of conventional 18-20 g Swiss albino mice to infection with the lethal GP strain of Coxsackie B-1 virus. The sex of the animal is not a determinant with regard to susceptibility to the infection. Germ-free Swiss albino mice (Charles River CD-1 strain) were significantly less susceptible to the infection with Coxsackie B-1 virus (GP strain) than were their conventional counterparts.
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Grunberg et al. (1964) studied Coxsackie B-1 virus infection. Germ-free status (gnotobiosis) vs. Conventional counterparts was evaluated on Susceptibility to infection. Germ-free Swiss albino mice were significantly less susceptible to Coxsackie B-1 virus infection than their conventional counterparts, while sex was not a determinant of susceptibility.
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