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April 1, 2006Diabetes CareOpen Access

Tissue Gene Expression of Renin-Angiotensin System in Human Type 2 Diabetic Nephropathy

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Population

74 patients with biopsy-proven renal diseases, including 66 nondiabetic and 8 diabetic patients.

Design

Cross-sectional

Authors

TKTadashi KonoshitaUniversity of FukuiSWShigeyuki WakaharaUniversity of FukuiSMShinichi MizunoKyushu University

Discussion

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Implication

Supports local RAS activation hypothesis in diabetic nephropathy; hypothesis-generating and should not yet change practice.

Structured PICO

P
Population
74 patients with biopsy-proven renal diseases, including 66 nondiabetic and 8 diabetic patients (type 2 diabetes with overt proteinuria).
C
Comparator
Nondiabetic patients with biopsy-proven renal diseases
O
Outcome
Expression levels of major components of the renin-angiotensin system (renin, renin receptor, angiotensinogen, ACE, ACE2, angiotensin II type 1 receptor, and angiotensin II type 2 receptor) in renal cortical biopsy specimenssurrogate

Renal tissue ACE gene expression is upregulated in type 2 diabetic nephropathy, suggesting local renin-angiotensin system activation despite systemic hyporeninemia.

Cite This Study

Konoshita et al. (2006) studied this question.

synapsesocial.com/papers/6a9088606bfd95d7bd4df28bhttps://doi.org/10.2337/diacare.29.04.06.dc05-1873
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Also Consider

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