March 1, 1999Journal of the American Society of Nephrology

Angiotensin II Receptor Type 1 Gene Expression in Human Glomerulonephritis and Diabetes Mellitus

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Population

Patients with glomerulonephritis or diabetic nephropathy, and controls with tumor-free tissue from tumor…

Design

Case-control

Authors

JWJürgen WagnerVogtland-Klinik FGFrank GehlenNephrologisches Zentrum Villingen-Schwenningen ACAndrzej CiechanowiczMedical University of Warsaw

Discussion

Member takes

Implication

AT1 receptor downregulation may reflect intrarenal angiotensin II excess in CKD; leaves open effects on RAAS inhibitor response.

Structured PICO

Population

Patients with glomerulonephritis (n=37 whole biopsy, n=22 microdissected glomeruli) or diabetic nephropathy (n=8), and controls with tumor-free tissue from tumor nephrectomies (n=9 whole biopsy, n=12 microdissected glomeruli).

Comparator

Tumor-free tissue from tumor nephrectomies

Outcome

Human AT1 receptor gene expression (mRNA levels)surrogate

AT1 receptor mRNA expression is downregulated in the glomeruli of patients with chronic renal disease, possibly as a regulatory response to high intrarenal angiotensin II concentrations.

Cite This Study

Wagner et al. (1999) studied this question.

synapsesocial.com/papers/6a8930a203fab2a419a5f797 https://doi.org/10.1681/asn.v103545

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Angiotensin II Receptor Type 1 Gene Expression in Human Glomerulonephritis and Diabetes Mellitus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II Receptor Type 1 Gene Expression in Human Glomerulonephritis and Diabetes Mellitus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider