Key result
Intragraft AT2R mRNA and protein expression was significantly greater in renal transplant patients with biopsy-proven chronic allograft nephropathy compared to those without (p=0.045).
Observational (n=23)
p-value: p=0.045
AT2R mRNA is expressed in adult human renal allografts and its association with matrix-modulating genes suggests a potential role in extracellular matrix regulation during chronic allograft nephropathy.
AT2R expression associates with chronic allograft nephropathy without implying causality; leaves open its role in matrix remodeling for prospective study.
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Becker et al. (2002) conducted an observational in Renal transplant recipients (n=23). Intragraft AT2R mRNA expression vs. No chronic allograft nephropathy and donor biopsy samples was evaluated on Presence of biopsy-proven chronic allograft nephropathy (p=0.045). Intragraft AT2R mRNA and protein expression was significantly greater in renal transplant patients with biopsy-proven chronic allograft nephropathy compared to those without (p=0.045).
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