Key result
Cardiac AT1R gene transcripts predicted the change in maximal intimal thickness over one year (regression coefficient 0.10; 95% CI 0.06-0.14; P<0.0001) following heart transplantation.
Why the study?
Do cardiac angiotensin II receptor gene transcripts predict the development of transplant coronary artery disease following heart transplantation?
Observational (n=50)
Do cardiac angiotensin II receptor gene transcripts predict the development of transplant coronary artery disease following heart transplantation?
Effect estimate: regression coefficient 0.10 (95% CI 0.06-0.14)
p-value: p=<0.0001
Cardiac AT1R gene transcription levels in endomyocardial biopsies predict the progression of transplant coronary artery disease at one year post-heart transplantation.
AT1R transcripts may identify higher-risk recipients for intensified surveillance; hypothesis-generating for targeted interventions in transplant vasculopathy.
No takes yet. Share an insight, caveat, or question.
Mohammed Yousufuddin (2004) conducted an observational in Transplant coronary artery disease (n=50). Cardiac angiotensin II type 1 (AT1R) and type 2 (AT2R) receptor gene transcription vs. Lower levels of gene transcription was evaluated on Change in maximal intimal thickness (CMIT) over one year (regression coefficient 0.10, 95% CI 0.06-0.14, p=<0.0001). Cardiac AT1R gene transcripts predicted the change in maximal intimal thickness over one year (regression coefficient 0.10; 95% CI 0.06-0.14; P<0.0001) following heart transplantation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: