October 25, 2012CirculationOpen Access

Myosin Light Chain Phosphorylation Is Critical for Adaptation to Cardiac Stress

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Population

Wild-type mice, Mylk3 gene-targeted mice, and transgenic mice overexpressing cMLCK specifically in…

Comparison

Pressure overload induced by transaortic… vs Wild-type mice undergoing TAC

Design

Preclinical

Authors

SWSonisha WarrenUniversity of Florida LBLaura E. BriggsUniversity of Ulster HZHuadong ZengNational High Magnetic Field Laboratory

Discussion

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Implication

cMLCK overexpression may attenuate decompensated HF in pressure-overload mice; hypothesis-generating for human therapeutic targeting.

Structured PICO

Population

Wild-type mice, Mylk3 gene-targeted (cMLCK knockout) mice, and transgenic mice overexpressing cMLCK specifically in cardiomyocytes

Intervention

Pressure overload induced by transaortic constriction (TAC)

Comparator

Wild-type mice undergoing TAC

Outcome

Development of heart failure and levels of phosphorylated MLC2v and cMLCKsurrogate

Accelerated cMLCK protein turnover by the ubiquitin-proteasome system reduces MLC2v phosphorylation, driving the transition from compensated hypertrophy to decompensated heart failure.

Cite This Study

Warren et al. (2012) studied this question.

synapsesocial.com/papers/6a908be07b6e700e2c8a60e1 https://doi.org/10.1161/circulationaha.112.116202

Topics

Heart failure HFrEF treatment

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Myosin Light Chain Phosphorylation Is Critical for Adaptation to Cardiac Stress

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Myosin Light Chain Phosphorylation Is Critical for Adaptation to Cardiac Stress

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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