Why the study?
Does sodium restriction augment the hypotensive effect of different classes of antihypertensive drugs in patients with essential hypertension?
Population
24 patients with essential hypertension
Comparison
Nicardipine 60 mg/d, propranolol 120 mg/d, or… vs Baseline regular sodium diet and…
Design
Other
Follow-up
4 weeks
Authors
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May support sodium restriction to enhance captopril efficacy; hypothesis-generating for class-specific sodium interactions in hypertension.
Does sodium restriction augment the hypotensive effect of different classes of antihypertensive drugs in patients with essential hypertension?
Sodium restriction augments the hypotensive effect of captopril but not nicardipine or propranolol, which is explained by their differing effects on the pressure-natriuresis curve.
Kimura et al. (1988) studied this question.
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