Flow Pulsatility Is a Critical Determinant of Oxidative Stress in Endothelial Cells
Population
Endothelial cells
Comparison
Exposure to pulsatile unidirectional or… vs Static cultures
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for pulsatile flow in endothelial oxidative stress; leaves open relevance to human atherogenesis.
Structured PICO
P
Population
Endothelial cells
I
Intervention
Exposure to pulsatile unidirectional or oscillatory flow patterns
C
Comparator
Static cultures
O
Outcome
Oxidative stress (NADH-dependent oxidase activity, superoxide anion production, p22phox mRNA level)surrogate
Flow pulsatility increases oxidative stress in endothelial cells via upregulation of NADH-dependent oxidase expression, providing insight into hemodynamic contributions to atherogenesis.
Cite This Study
Silacci et al. (2001) studied this question.