Why the study?
Does myocardial infarction-induced heart failure alter endothelial NO, superoxide, and peroxynitrite production in normotensive and hypertensive rats?
Population
Wistar-Kyoto rats and spontaneously hypertensive rats with failing hearts after myocardial infarction
Comparison
Myocardial infarction induced by permanent… vs Sham operation
Design
Preclinical
Follow-up
8 weeks
Authors
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Post-MI endothelial NO reduction and peroxynitrite rise may worsen HF in hypertension; leaves open human translation and targeted therapies.
Does myocardial infarction-induced heart failure alter endothelial NO, superoxide, and peroxynitrite production in normotensive and hypertensive rats?
Heart failure after myocardial infarction is associated with decreased NO availability and increased superoxide and peroxynitrite production in aortic endothelial cells, particularly in hypertensive rats.
Wiemer et al. (2001) studied this question.
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