Efficient and green pathway for one-pot synthesis of spirooxindoles in the presence of CuO nanoparticles

In this research, a new, green and eco-friendly method for the synthesis of spirooxindole derivatives was presented. The reaction was performed at room temperature in the presence of catalytic amounts (4 mol.%) of CuO nanoparticles and products were obtained in high to excellent yields. Low-cost high-efficiency reusable catalyst, short reaction times at room temperature, high to excellent yield and easy purification of products are the main advantages to this protocol. The pronounced advantages of catalyst are expected to create a new pathway for the synthesis of spirooxindoles.