The response to procainamide during electrophysiologic study for sustained ventricular tachyarrhythmias predicts the response to other medications.
Why the study?
Does the response to procainamide during electrophysiologic study predict the response to other conventional antiarrhythmic agents in patients with inducible sustained ventricular tachyarrhythmias?
Population
126 patients with inducible sustained ventricular tachyarrhythmias
Comparison
Procainamide administration during… vs Patients in whom ventricular tachycardia…
Design
Cohort
Authors
Discussion
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Member takes
Implication
Procainamide response may guide antiarrhythmic selection in EP studies; hypothesis-generating and requires prospective outcome validation.
Structured PICO
Does the response to procainamide during electrophysiologic study predict the response to other conventional antiarrhythmic agents in patients with inducible sustained ventricular tachyarrhythmias?
P
Population
126 patients with inducible sustained ventricular tachyarrhythmias
I
Intervention
Procainamide administration during electrophysiologic study
C
Comparator
Patients in whom ventricular tachycardia remained inducible after procainamide (non-responders)
O
Outcome
Response to other conventional antiarrhythmic agents and combinations of agents (prevention of ventricular tachycardia induction during serial electrophysiologic studies)surrogate
The response to procainamide during electrophysiologic study accurately predicts the efficacy of other conventional antiarrhythmic agents in preventing ventricular tachycardia induction.
Cite This Study
Waxman et al. (1983) studied this question.