Carotid Artery Wall Thickness and Risk of Stroke Subtypes
Why the study?
Does higher carotid intima-media thickness increase the risk of stroke subtypes in adults free of clinical stroke?
Population
13,560 men and women aged 45 to 64 years and free of clinical stroke from the Atherosclerosis Risk in…
Comparison
Higher carotid intima-media thickness levels vs Lowest quintile of carotid intima-media thickness
Design
Cohort
Follow-up
average 15.7 years
Authors
Discussion
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Member takes
Implication
IMT elevation signals higher stroke subtype risks; leaves open whether it improves stratification beyond standard factors in primary prevention.
Structured PICO
Does higher carotid intima-media thickness increase the risk of stroke subtypes in adults free of clinical stroke?
P
Population
13,560 men and women aged 45 to 64 years and free of clinical stroke from the Atherosclerosis Risk in Communities (ARIC) study
I
Intervention
Higher carotid intima-media thickness levels (highest quintile ≥0.85 mm)
C
Comparator
Lowest quintile of carotid intima-media thickness (<0.61 mm)
O
Outcome
Incident strokes (hemorrhagic and ischemic subtypes including lacunar, nonlacunar, and cardioembolic)hard clinical
Higher carotid intima-media thickness is associated with an increased risk of all stroke subtypes, with the strongest associations observed for nonlacunar and cardioembolic strokes.
Cite This Study
Ohira et al. (2010) studied this question.