Population
Adult rat ventricular myocytes
Comparison
Short-term culture with acetaldehyde, with or… vs Control myocytes (implied)
Design
Preclinical
Follow-up
4 to 6 hours
Authors
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Acetaldehyde may contribute to alcoholic cardiomyopathy; leaves open whether oxidase or peroxidation inhibitors offer human therapeutic targets.
Acetaldehyde depresses cardiomyocyte mechanical function at micromolar levels, likely via mechanisms involving CYP oxidase, xanthine oxidase, and lipid peroxidation, providing insight into the pathogenesis of alcoholic cardiomyopathy.
Aberle et al. (2003) studied this question.
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