April 29, 2006AJP Heart and Circulatory Physiology
Biphasic changes in cardiac excitation-contraction coupling early in chronic alcohol exposure
Key result
Chronic ethanol exposure in rats induced biphasic changes in cardiac excitation-contraction coupling, with positive inotropy at 1 month transitioning to negative inotropy at 3 months.
Why the study?
How does the transition from acute to chronic ethanol exposure affect cellular excitation-contraction coupling in a rat model of alcoholic cardiomyopathy?
Population
Rat model known to develop alcohol-induced cardiomyopathy (isolated rat ventricular cardiac myocytes)
Comparison
Acute ethanol exposure and chronic ethanol… vs Control
Design
Preclinical
Follow-up
1 and 3 months
Authors
Discussion
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Implication
May indicate biphasic EC coupling shifts in early alcohol exposure; leaves open translation to human cardiomyopathy.
Structured PICO
How does the transition from acute to chronic ethanol exposure affect cellular excitation-contraction coupling in a rat model of alcoholic cardiomyopathy?
P
Population
Rats fed a diet containing approximately 9% (vol/vol) ethanol for 1 to 3 months to study the acute-to-chronic transition of alcohol-induced cardiomyopathy.
E
Exposure
Acute ethanol exposure and chronic ethanol exposure (diet containing approximately 9% vol/vol ethanol for 1 month and 3 months)
C
Comparator
Control (implied, not explicitly detailed in abstract)
O
Outcome
Changes in cellular excitation-contraction (EC) coupling parameters (cell shortening, Ca2+ transient amplitude, Ca2+ decay rate, and sarcoplasmic reticulum Ca2+ content)surrogate
Chronic ethanol exposure induces biphasic changes in cardiac excitation-contraction coupling during the asymptomatic transition phase before the onset of alcoholic cardiomyopathy.
Cite This Study
Aistrup et al. (2006) studied Alcohol-induced cardiomyopathy. Ethanol (EtOH) exposure was evaluated on Cellular excitation-contraction (EC) coupling parameters. Chronic ethanol exposure in rats induced biphasic changes in cardiac excitation-contraction coupling, with positive inotropy at 1 month transitioning to negative inotropy at 3 months.