Why the study?
Does chronic alcohol exposure alter cytosolic Ca2+ handling to induce changes in cardiac contractility in rats?
Population
Rats (model of chronic alcohol exposure)
Comparison
36% ethanol drinking for 7 months vs Age-matched controls
Design
Preclinical
Follow-up
7 months
Authors
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Alcohol-induced contractile dysfunction occurs without cytosolic Ca2+ changes in rats; hypothesis-generating for myofilament mechanisms before human studies.
Does chronic alcohol exposure alter cytosolic Ca2+ handling to induce changes in cardiac contractility in rats?
Chronic alcohol-induced changes in myocardial contractility are not due to altered cytosolic Ca2+ handling, but likely result from changes at the myofilament level.
Figueredo et al. (1998) studied this question.
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