Why the study?
Does DHEA reduce collagen type I synthesis and cardiac fibrosis in cardiac fibroblasts and angiotensin II-treated rats?
Population
Cultured cardiac fibroblasts and Sprague-Dawley rats treated with angiotensin II for 8 weeks to induce…
Comparison
Dehydroepiandrosterone (10 M in vitro… vs Controls
Design
Preclinical
Follow-up
8 weeks (in vivo)
Authors
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DHEA may inhibit cardiac fibrosis independently of blood pressure in rats; hypothesis-generating for human translation.
Does DHEA reduce collagen type I synthesis and cardiac fibrosis in cardiac fibroblasts and angiotensin II-treated rats?
DHEA directly attenuates collagen type I synthesis and cardiac fibrosis, providing a potential mechanism for its inverse relationship with cardiovascular mortality.
Iwasaki et al. (2005) studied this question.
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