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February 2, 1997European Heart Journal

Circulating cardiac-specific autoantibodies as markers of autoimmunity in clinical and biopsy-proven myocarditis

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Why the study?

Are circulating cardiac-specific autoantibodies more frequent in patients with clinical myocarditis compared to ischaemic or normal controls?

Population

53 patients with clinical myocarditis from the Myocarditis Treatment Trial, mean age 42 +/- 15 years, 35…

Design

Case-control

Authors

ACAlida L.P. CaforioGeneral CardiologyJGJ. H. GoldmanSt George's HospitalAHA.J. HavenUniversity College London

Discussion

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Implication

Supports autoimmune involvement in myocarditis; leaves open whether antibody testing should inform diagnosis or trials.

Structured PICO

Are circulating cardiac-specific autoantibodies more frequent in patients with clinical myocarditis compared to ischaemic or normal controls?

P
Population
53 patients with clinical myocarditis (24 with histological myocarditis by Dallas criteria) from the Myocarditis Treatment Trial, mean age 42 +/- 15 years, 35 males, compared with ischaemic and normal controls.
C
Comparator
Ischaemic controls (n=186 for immunofluorescence, n=92 for ELISA) and normal controls (n=270 for immunofluorescence, n=203 for ELISA)
O
Outcome
Presence of cardiac autoantibodies assessed by indirect immunofluorescence and anti-alpha-myosin enzyme-linked immunosorbent assay (ELISA)surrogate

Cardiac-specific autoantibodies are significantly more prevalent in patients with clinical myocarditis compared to controls, supporting an autoimmune component in a subset of patients regardless of biopsy findings.

Cite This Study

Caforio et al. (1997) studied this question.

synapsesocial.com/papers/6a90d90655de849fda7a66f0https://doi.org/10.1093/oxfordjournals.eurheartj.a015230

Topics

Myocarditis
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Active Myocarditis in the Spectrum of Acute Dilated Cardiomyopathies1985 · 569 citations
  2. 2Clinical and prognostic significance of detection of enteroviral RNA in the myocardium of patients with myocarditis or dilated cardiomyopathy.1994 · 274 citations
  3. 3Role of autoimmunity in dilated cardiomyopathy1994 · 55 citations
  4. 4Autoantibodies in against human ventricular myosin in sera of patients with acute and chronic myocarditis1994 · 93 citations
  5. 5Immunosuppression for Myocarditis1995 · 37 citations