Population
Acutely dissociated guinea pig ventricular myocytes
Comparison
Isoflurane and protein tyrosine kinase inhibitors vs Inactive analog of genistein or baseline…
Design
Preclinical
Authors
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Hypothesis-generating for isoflurane cardioprotection via K(ATP) modulation in animals; leaves open human translation and clinical relevance.
The protein tyrosine kinase-protein tyrosine phosphatase signaling pathway regulates cardiac sarcolemmal K(ATP) channels and modulates their responsiveness to isoflurane, which may play a role in cardioprotection by volatile anesthetics.
Stadnicka et al. (2002) studied this question.
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