Key result
Brief exposure to isoflurane increased pinacidil-elicited IKATP from 3.8 pA/pF to 15.6 pA/pF (P<0.05), an effect mediated by protein kinase C-delta.
Population
Single isolated rat ventricular cardiomyocytes
Comparison
10 min exposure to isoflurane followed by 10 or… vs Anesthetic-free conditions
Design
Preclinical
Authors
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Extends mechanistic insight into anesthetic preconditioning; leaves open clinical translation from animal models.
Absolute Event Rate: 15.6% vs 3.8%
p-value: p=< 0.05
Isoflurane induces prolonged sensitization of the cardiac sarcKATP channel via a protein kinase C-delta-mediated mechanism, contributing to anesthetic preconditioning.
Marinović et al. (2005) studied this question. Isoflurane vs. Anesthetic-free conditions was evaluated on Mean density of IKATP elicited by pinacidil (p=< 0.05). Brief exposure to isoflurane increased pinacidil-elicited IKATP from 3.8 pA/pF to 15.6 pA/pF (P<0.05), an effect mediated by protein kinase C-delta.
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