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July 29, 2014Cardiovascular DiabetologyOpen Access

DPP-4 inhibitor and alpha-glucosidase inhibitor equally improve endothelial function in patients with type 2 diabetes: EDGE study

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Why the study?

Does sitagliptin improve flow-mediated dilatation compared to voglibose in patients with type 2 diabetes inadequately controlled on standard oral therapy?

Population

66 patients with type 2 diabetes who did not achieve the treatment goal with sulfonylurea, metformin or…

Comparison

Sitagliptin for 12 weeks vs Voglibose for 12 weeks

Design

RCT, randomized

Follow-up

12 weeks

Authors

KNKazufumi NakamuraHOHiroki OeHKHajime Kihara

Discussion

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Overview

Both agents may be used interchangeably to improve endothelial function in T2DM; extends comparative evidence on DPP-4 versus alpha-glucosidase inhibition.

Structured PICO

Does sitagliptin improve flow-mediated dilatation compared to voglibose in patients with type 2 diabetes inadequately controlled on standard oral therapy?

P
Population
66 patients with type 2 diabetes who did not achieve the treatment goal with sulfonylurea, metformin or pioglitazone treatment
I
Intervention
Sitagliptin for 12 weeks
C
Comparator
Voglibose for 12 weeks
O
Outcome
Change in flow-mediated dilatation (ΔFMD) of the brachial artery in the fasting state from baseline to 12 weekssurrogate

Sitagliptin and voglibose equally improve endothelial function in patients with type 2 diabetes, with sitagliptin showing a more favorable tolerability profile and increasing circulating CD34.

Cite This Study

Nakamura et al. (2014) studied this question.

synapsesocial.com/papers/6a90eaf9c39ca0eda182ff00https://doi.org/10.1186/s12933-014-0110-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dipeptidyl Peptidase‐4 Inhibitors Attenuate Endothelial Function as Evaluated by Flow‐Mediated Vasodilatation in Type 2 Diabetic Patients2013 · 125 citations
  2. 2Dipeptidyl Peptidase-4 Inhibitor, Sitagliptin, Improves Endothelial Dysfunction in Association With Its Anti-Inflammatory Effects in Patients With Coronary Artery Disease and Uncontrolled Diabetes2013 · 199 citations
  3. 3Hyperglycemia rapidly suppresses flow-mediated endothelium- dependent vasodilation of brachial artery1999 · 682 citations
  4. 4Reduction of postchallenge hyperglycaemia prevents acute endothelial dysfunction in subjects with impaired glucose tolerance2005 · 80 citations
  5. 5Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery2002 · 4,614 citations