Why the study?
Does oxprenolol and/or indomethacin reduce renin and aldosterone levels in normal subjects on a low sodium diet?
Does oxprenolol and/or indomethacin reduce renin and aldosterone levels in normal subjects on a low sodium diet?
Oxprenolol and indomethacin independently and additively reduce plasma renin activity in normal subjects on a low sodium diet, suggesting roles for both the sympathetic nervous system and prostaglandins.
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Oxprenolol and indomethacin additively normalize PRA on low-sodium intake; extends mechanistic evidence for sympathetic and prostaglandin control of renin.
Pedrinelli et al. (1982) studied this question.
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