Why the study?
Does diclofenac sodium alter prothrombin times in hospitalized patients stabilized on acenocoumarol?
Population
32 hospitalized patients stabilized on concurrent anticoagulant therapy with acenocoumarol
Comparison
Diclofenac sodium vs Placebo
Design
RCT, double-blind
Follow-up
4 weeks
Authors
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Supports diclofenac coadministration without prothrombin time adjustment in acenocoumarol patients; confirms absence of interaction in this RCT.
Does diclofenac sodium alter prothrombin times in hospitalized patients stabilized on acenocoumarol?
Diclofenac sodium does not appear to significantly interact with the oral anticoagulant acenocoumarol to alter prothrombin times.
Michot et al. (1975) studied this question.
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