Why the study?
Does captopril reduce tumor growth in a lung cancer xenograft mouse model?
Population
Mice implanted with human lung adenocarcinoma epithelial cell line in the lower right flank, n=12
Comparison
Captopril (3.0 mg/mouse) administered for 5 days vs Saline (1000 μl/mouse) administered for 5 days
Design
Preclinical
Follow-up
5 days
Authors
Loading...
Hypothesis-generating for captopril in lung cancer; leaves open translation to patients pending clinical trials.
Does captopril reduce tumor growth in a lung cancer xenograft mouse model?
Captopril demonstrated a potential tumor growth-inhibitory effect in a lung cancer xenograft mouse model, as assessed by 18F-FDG-PET/CT.
Nakaya et al. (2015) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: