Restricted TMEV infection induces apoptosis in murine macrophage cell lines, which may relate to viral persistence in the central nervous system.
Apoptosis in TMEV-infected macrophages may promote viral persistence; leaves open its contribution to CNS demyelination in vivo.
Increasing evidence suggests that macrophages (M(phi)s) are necessary for persistence of Theiler's murine encephalomyelitis virus (TMEV) in the mouse central nervous system. Analysis of BeAn virus infection in the Mphi cell lines P388D1, J774A.1 and PU5-1.8, which are intermediate in their state of differentiation and resemble multifunctional resident M(phi)s, revealed restricted TMEV growth. As a result of the restricted infection, these Mphi cell lines were induced to undergo apoptosis as demonstrated by cellular morphology, DNA fragmentation, caspase protease activity, and in individual cells, by terminal deoxytransferase dUTP nick-end labelling (TUNEL).
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Jelachich et al. (1999) studied this question.
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