In the teleost heart, catecholamines improve the tension development in isolated muscle strips and increase stroke volume (SVH) in perfused hearts working at sub-physiological levels (see Laurent, Holmgren & Nilsson, 1983 and Farrell, 1984 for recent reviews). Adrenalin (AD) can also restore or improve tension development during acidosis and anoxia (Gesser, Andresen, Brams & Sund-Laursen, 1982). However, physiological concentrations of AD do not increase SVH in any marked or consistent fashion in either intact fish or perfused hearts working at physiological levels (see Farrell, 1984), and only restore control levels of cardiac output in perfused hearts exposed to pH 7·4 at constant preload (Farrell, MacLeod, Driedzic & Wood, 1983). These observations pose the question: what is the role of catecholamine-mediated inotropic stimulation in fish?
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Anthony P. Farrell (1985) studied this question.
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