Key result
Increases in preload are likely more important than increases in extracellular calcium to improve cardiac performance in the sea raven heart during extracellular acidosis.
In the sea raven heart model, increasing preload appears more effective than increasing extracellular calcium for improving cardiac performance during extracellular hypercapnic acidosis.
Hypothesis-generating in a fish model; leaves open any translation to mammalian or human acidosis management.
The effect of extracellular calcium ([Ca2+]e) on the performance of the in situ perfused sea raven heart was evaluated under nonacidotic, acidotic, and high work load conditions. Increases in [Ca2+]e improved power output of the nonacidotic heart and restored control levels of power output to the heart exposed to hypercapnic acidosis (1.8% CO2, pH 7.4). Extracellular acidosis severely curtailed the scope for cardiac work (increased cardiac output and afterload), and only a 50% increase in the control, nonacidotic power output was possible with increases in preload and saturating levels of [Formula: see text]. It is suggested that increases in preload are probably more important than increases in [Ca2+]e to improve cardiac performance in the seas raven heart during extracellular acidosis.
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Farrell et al. (1984) studied Extracellular hypercapnic acidosis. Extracellular calcium and preload vs. Control conditions was evaluated on Cardiac performance (power output). Increases in preload are likely more important than increases in extracellular calcium to improve cardiac performance in the sea raven heart during extracellular acidosis.
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