Key result
Combined anoxia and acidosis depress cardiac rate and reduce turtle ventricular contractile force by ~83%.
Why the study?
The effects of combined anoxia and acidosis on turtle cardiac tissue contractile force and acid-base state were not fully characterized.
Population
Ventricular strips from the turtle Chrysemys picta bellii
Comparison
Combined anoxia and acidosis vs control, with variations in pacing and extracellular Ca2+ concentration
Design
Preclinical experimental study
Follow-up
1 hour
Authors
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Anoxia-acidosis exposure impairs turtle cardiac strips in vitro; leaves open translation to mammalian ischemia and requires further validation.
Combined anoxia and acidosis profoundly depresses cardiac function in turtle ventricular strips, though hypercalcemia and bradycardia offer some improvement.
Wasser et al. (1990) studied turtle cardiac tissue exposed to combined anoxia and acidosis. combined anoxia and acidosis (pH 7.0) vs. control strips was evaluated on contractile force and rate. Exposure of turtle ventricular strips to 1 hour of combined anoxia and acidosis significantly depressed cardiac rate and contractile force to 54% and 17.1% of control values, respectively.
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