Why the study?
Does passive transmission of neutralizing antibodies protect mice against Coxsackie B-1 virus infection?
Population
Mice litters (4-day-old and 17-day-old) born to immune and non-immune mothers
Comparison
Passive neutralizing antibodies specific to… vs Non-immune controls
Design
Preclinical
Authors
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Hypothesis-generating for maternal antibody protection in neonatal enteroviral infection; human studies needed before clinical consideration.
Does passive transmission of neutralizing antibodies protect mice against Coxsackie B-1 virus infection?
Passive maternal antibodies protect neonatal mice from Coxsackie B-1 virus-induced tissue damage and viral multiplication, depending on the route of inoculation.
Grodums et al. (1964) studied this question.
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