The 2007 US outbreak strain of Coxsackievirus B1 showed significant genetic divergence from the reference strain.
Divergent CVB1 outbreak strains may require updated diagnostic references; leaves open effects on pathogenesis or immunity.
In 2007, clusters of severe coxsackievirus B1 (CVB1) infection occurred across the United States, and CVB1 became the most commonly reported enterovirus. The complete genome sequence of CVB1 isolated from an infant (CVB1-Chi07) was examined and found to be divergent from the Conn5 reference strain, with 80% and 96% similarities at the nucleotide and amino acid levels, respectively.
No takes yet. Share an insight, caveat, or question.
Quinn et al. (2014) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: