January 1, 2000Japanese Heart JournalOpen Access

Advantage of Recombinant Technology for the Identification of Cardiac Myosin Epitope of Severe Autoimmune Myocarditis in Lewis Rats.

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Population

Lewis rats (animal model for experimental autoimmune myocarditis)

Comparison

Recombinant peptide fragment of self-cardiac… vs Fragment with excision of 12 amino acids from…

Design

Preclinical

Authors

KKKen KohnoKitasato University YTYohtaroh TakagakiUniversity of Washington YNYoichi Nakajima

Discussion

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Implication

Pinpoints a myocarditis-inducing epitope in rats; leaves open translation to human disease or therapy.

Structured PICO

Population

Lewis rats (animal model for experimental autoimmune myocarditis)

Intervention

Recombinant peptide fragment of self-cardiac myosin heavy chain (CMHC) residues 1107 to 1186

Comparator

Fragment with excision of 12 amino acids from residues 1131 to 1143

Outcome

Induction of severe myocarditis (immunogenicity)surrogate

Recombinant technology successfully identified the specific immunogenic epitope (residues 1107-1186, specifically requiring 1131-1143) of cardiac myosin responsible for experimental autoimmune myocarditis in Lewis rats.

Cite This Study

Kohno et al. (2000) studied this question.

synapsesocial.com/papers/6a910eccefab70d99b73e09d https://doi.org/10.1536/jhj.41.67

Topics

Myocarditis

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Advantage of Recombinant Technology for the Identification of Cardiac Myosin Epitope of Severe Autoimmune Myocarditis in Lewis Rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Advantage of Recombinant Technology for the Identification of Cardiac Myosin Epitope of Severe Autoimmune Myocarditis in Lewis Rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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