Key result
A peptide fragment of beta-cardiac myosin heavy chain was as capable of provoking severe autoimmune myocarditis in Lewis rats as the corresponding alpha-cardiac myosin heavy chain fragment.
Why the study?
Does a peptide fragment of beta-CMHC provoke autoimmune myocarditis as severely as the corresponding alpha-CMHC fragment in Lewis rats?
Population
Lewis rats
Comparison
Immunization with recombinant peptide fragment… vs Immunization with corresponding alpha-cardiac…
Design
Preclinical
Authors
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Extends experimental myocarditis autoantigens to beta-myosin; leaves open human relevance and clinical translation.
Does a peptide fragment of beta-CMHC provoke autoimmune myocarditis as severely as the corresponding alpha-CMHC fragment in Lewis rats?
Beta-CMHC is as pathogenic as alpha-CMHC in provoking experimental autoimmune myocarditis, challenging the belief that alpha-CMHC is primarily responsible.
Kohno et al. (2001) studied Autoimmune myocarditis. beta-CMHC peptide fragment (amino acid residues 1107-1164) vs. alpha-CMHC peptide fragment (amino acid residues 1107-1164) was evaluated on Severity of myocarditis (histological scoring). A peptide fragment of beta-cardiac myosin heavy chain was as capable of provoking severe autoimmune myocarditis in Lewis rats as the corresponding alpha-cardiac myosin heavy chain fragment.
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