Why the study?
Does nitroprusside infusion alter left ventricular pressure-volume relations differently in patients with versus without heart failure symptoms?
Population
21 patients without coronary artery disease, including 8 without symptoms of left ventricular failure and 13…
Comparison
Nitroprusside infusion vs Baseline measurements before nitroprusside…
Design
Cohort
Authors
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Supports selective nitroprusside response in symptomatic HF; hypothesis-generating for LV pressure-volume differences and needs prospective validation.
Does nitroprusside infusion alter left ventricular pressure-volume relations differently in patients with versus without heart failure symptoms?
Nitroprusside infusion improves forward flow (cardiac index and stroke volume) specifically in patients with heart failure symptoms, reflecting underlying differences in active and passive left ventricular pressure-volume relations.
Merillon et al. (1979) studied this question.
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