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January 1, 1990AJP Endocrinology and Metabolism

Measurement of myocardial glycogen synthesis in diabetic and fasted rats

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Population

Diabetic and fasted rats, and normal control rats

Comparison

50-min infusion of D-[1-13C]-glucose and insulin vs Normal control rats

Design

Preclinical

Follow-up

50 minutes

Authors

MLMaren R. LaughlinNational Institutes of HealthWPWilliam A. PetitThe Hospital of Central ConnecticutRSRobert G. ShulmanYale University

Discussion

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Implication

Confirms glycogen synthase as rate-limiting for myocardial glycogen synthesis; leaves open human translation from this animal model.

Structured PICO

P
Population
Diabetic and fasted rats, and normal control rats
I
Intervention
50-min infusion of D-[1-13C]-glucose (10 mg/min) and insulin (1 U/min)
C
Comparator
Normal control rats
O
Outcome
In vivo rate of heart glycogen synthesis measured by 13C-nuclear magnetic resonancesurrogate

Glycogen synthase is the rate-limiting enzyme for myocardial glycogen synthesis in normal, diabetic, and fasted rats.

Cite This Study

Laughlin et al. (1990) studied this question.

synapsesocial.com/papers/6a911524efab70d99b73e2f0https://doi.org/10.1152/ajpendo.1990.258.1.e184
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effects of Acute and Chronic Diabetes on Myocardial Metabolism in Rats1984 · 90 citations
  2. 2Insulin-mediated reduction of whole body protein breakdown. Dose-response effects on leucine metabolism in postabsorptive men.1985 · 372 citations
  3. 3Regulation of muscle glycogen synthetase by metabolites. Differential effects on the I and D forms1968 · 149 citations
  4. 4Effect of fatty acids on glucose production and utilization in man.1983 · 1,058 citations
  5. 5NMR measurements of in vivo myocardial glycogen metabolism.1988 · 70 citations