The ACE D allele frequency among Omanis is 0.71, aligning with other Arab and African populations but differing significantly from East Asian populations.
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ACE allele frequencies in Omanis warrant no practice change; extends genetic epidemiology data for Arab populations.
OBJECTIVE: To describe the angiotensin converting enzyme (ACE) genotype frequencies among Omani Arabs. METHOD: A polymerase chain reaction (PCR) test, based on separation of different size DNA fragments, was developed to test the presence or absence (polymorphism) of a small DNA deletion in the ACE gene. The subjects were 124 Omani Arab students of Sultan Qaboos University, Muscat. RESULTS: The frequency of the I allele was 0.29, while that of the D allele was 0.71. The gene frequency distribution did not deviate from Hardy-Weinberg equilibrium. CONCLUSIONS: The frequency of D allele among Omanis is similar to that among other Arabs and Africans, but differs significantly from that among the Japanese and Chinese.
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Al‐Hinai et al. (2002) studied this question.
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