Aspirin and Postoperative Bleeding

Letters and Corrections1 January 1979Aspirin and Postoperative BleedingRICHARD S. STEIN, M.D.RICHARD S. STEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-1-123_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Torosian and colleagues (1) have reported increased postoperative bleeding in patients receiving aspirin within a week of surgery. Although the effects of aspirin last for the lifetime of exposed platelets, 5 to 7 days, the bleeding time is normal within 2 days after administration of aspirin (2, 3), and platelets collected from donors receiving aspirin 36 h before donation can correct abnormal bleeding times in recipients (4). Although aspirin-exposed platelets do not release their own ADP, if sufficient normal platelets are present the entire platelet pool appears to function normally, at least as measured by bleeding time....References1. TOROSIANMICHELSONMORGANROTHMACVAUGH MEJH: Aspirin- and Coumadin®-related bleeding after coronary-artery bypass graft surgery. Ann Intern Med 89:325-328, 1978 LinkGoogle Scholar2. HIRSHSTREETCADOAMY JDJH: Relation between bleeding time and platelet connective tissue reaction after aspirin. Blood 41:369-377, 1973 CrossrefMedlineGoogle Scholar3. STUARTMURPHYOSKIEVANSDONALDSONGARDNER MSFAMF: Platelet function in recipients of platelets from donors ingesting aspirin. N Engl J Med 287:1105-1109, 1972 CrossrefMedlineGoogle Scholar4. O'BRIEN J: Effects of salicylates on human platelets. Lancet 1:779-783, 1968 CrossrefMedlineGoogle Scholar1. TOROSIANMICHELSONMORGANROTHMACVAUGH MEJH: Aspirin- and Coumadin®-related bleeding after coronary-artery bypass graft surgery. Ann Intern Med 89:325-328, 1978 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD S. STEIN, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1979Volume 90, Issue 1Page: 123-123KeywordsAdenosine diphosphateAspirinHemorrhagePlateletsSurgery ePublished: 1 December 2008 Issue Published: 1 January 1979 PDF downloadLoading ...