What question did this study set out to answer?

To determine whether positive end-expiratory pressure (PEEP) alters intrinsic ventricular function independently of changes in cardiac preload.

December 1, 1981Journal of Applied Physiology

Effect of positive end-expiratory pressure on canine ventricular function curves

View Full Paper

Ask AI

Bookmark

Authors

JMJohn J. MariniUniversity of Minnesota System BCB. H. CulverUniversity of Minnesota JBJohn ButlerWestern University

Discussion

Member takes

Implication

Physiological animal experiment demonstrates preserved ventricular function during positive end-expiratory pressure ventilation in dogs, suggesting hemodynamic changes stem from reduced preload...

Key Points

To determine whether positive end-expiratory pressure (PEEP) alters intrinsic ventricular function independently of changes in cardiac preload.
Ventricular function curves were constructed in 14 anesthetized dogs under closed- and open-chest conditions.
Systemic venous blood was diverted via an external circuit to control right atrial return from 1 to 4.5 l/min before and after applying 15 cmH2O PEEP.
Juxtacardiac pressures were recorded using thin fluid-filled sensors to estimate transmural pressure, with sensitivity to cardiac depression verified using propranolol.
Ventricular function curves generated with and without 15 cmH2O PEEP were statistically indistinguishable when plotted against transmural pressure.
Propranolol administration confirmed that the method was sensitive enough to detect true intrinsic myocardial depression.
Hemodynamic alterations during PEEP ventilation resulted entirely from elevated juxtacardiac pressure and reduced preload, rather than intrinsic myocardial dysfunction.

Cite This Study

Marini et al. (1981) studied this question.

synapsesocial.com/papers/6a912998fbd14437d06f1cd3 https://doi.org/10.1152/jappl.1981.51.6.1367

View Full Paper

Ask AI

Bookmark

Implication

Physiological animal experiment demonstrates preserved ventricular function during positive end-expiratory pressure ventilation in dogs, suggesting hemodynamic changes stem from reduced preload...

Effect of positive end-expiratory pressure on canine ventricular function curves

Discussion

Member takes

Implication

Key Points

Cite This Study

Effect of positive end-expiratory pressure on canine ventricular function curves

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider