gamma 2-Thymidine kinase chimeras are identically transcribed but regulated a gamma 2 genes in herpes simplex virus genomes and as beta genes in cell genomes.
Population
Cells transfected with gamma 2-thymidine kinase (TK) chimeric genes (pRB3038 or pRB3048)
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Should not alter clinical viral management; leaves open differential gamma 2 gene regulation in host versus viral genomes.
Structured PICO
P
Population
Cells transfected with gamma 2-thymidine kinase (TK) chimeric genes (pRB3038 or pRB3048)
I
Intervention
Superinfection with HSV-1(F) delta 305, ts502 delta 305, or tsHA1 delta 305
O
Outcome
TK induction and gene expression regulation
Gamma 2 genes resident in host cells are regulated differently (as beta genes) compared to when they are in the viral genome (as gamma 2 genes).
Cite This Study
Silver et al. (1985) studied this question.