Why the study?
Pulmonary function is impaired after major abdominal surgery, and investigators tested whether an intraoperative colloid-based goal-directed fluid management strategy improves postoperative pulmonary function compared with crystalloids.
Does intraoperative goal-directed colloid administration improve postoperative pulmonary function parameters compared to goal-directed crystalloid administration in patients undergoing major open abdominal surgery?
Population
60 patients undergoing major open abdominal surgery
Comparison
Lactated Ringer's solution vs 6% hydroxyethyl starch 130/0.4
Design
Preplanned single-center randomized controlled substudy
Follow-up
48 hours postoperatively
Authors
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No pulmonary benefit from colloid versus crystalloid goal-directed therapy; reinforces crystalloid preference given equivalent spirometry and lower cost.
Does intraoperative goal-directed colloid administration improve postoperative pulmonary function parameters compared to goal-directed crystalloid administration in patients undergoing major open abdominal surgery?
Intraoperative goal-directed colloid administration does not significantly improve postoperative pulmonary function parameters compared to crystalloids in patients undergoing open abdominal surgery.
Obradovic et al. (2022) studied this question.
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