Key result
Goal-directed intraoperative administration of colloids did not significantly reduce perioperative levels of inflammatory cytokines compared to crystalloids in patients undergoing open abdominal surgery.
Why the study?
Because colloids require less volume to achieve hemodynamic endpoints than crystalloids, researchers tested whether a goal-directed colloid regimen attenuates the inflammatory response compared to a goal-directed crystalloid regimen.
Does goal-directed colloid administration reduce perioperative inflammatory markers compared to goal-directed crystalloid administration in patients undergoing moderate- to high-risk open abdominal surgery?
Population
Patients undergoing moderate- to high-risk open abdominal surgery (n = 58 crystalloid, n = 62 colloid)
Comparison
Goal-directed hydroxyethyl starch 6% 130/0.4 vs goal-directed lactated Ringer's solution
Design
Randomized controlled trial substudy
Follow-up
Postoperative day four
Authors
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Goal-directed colloid and crystalloid regimens show similar inflammatory marker levels; leaves open differential effects on clinical outcomes in abdominal surgery.
RCT (n=120)
Computer-generated codes
No
Does goal-directed colloid administration reduce perioperative inflammatory markers compared to goal-directed crystalloid administration in patients undergoing moderate- to high-risk open abdominal surgery?
Absolute Event Rate: 104.1% vs 124.3%
p-value: p=0.60
Goal-directed colloid administration does not significantly attenuate the perioperative inflammatory response compared to goal-directed crystalloid administration in patients undergoing moderate- to high-risk abdominal surgery.
Obradovic et al. (2020) conducted an RCT in Moderate- to high-risk open abdominal surgery (n=120). Goal-directed colloid (hydroxyethyl starch 6% 130/0.4) vs. Goal-directed crystalloid (lactated Ringer's solution) was evaluated on Area under the curve of Interleukin 6 (IL 6) levels (pg.mL-1.d) (p=0.60). Goal-directed intraoperative administration of colloids did not significantly reduce perioperative levels of inflammatory cytokines compared to crystalloids in patients undergoing open abdominal surgery.
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