March 1, 2005Diabetes CareOpen Access

Blood Glucose and Heart Failure in Nondiabetic Patients

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Why the study?

Does higher baseline blood glucose increase the incidence of heart failure in nondiabetic patients?

Population

20,810 nondiabetic patients. Excluded: prior diagnosis of diabetes, diagnosis of heart failure <1 year after…

Comparison

Higher baseline morning blood glucose levels vs Baseline morning blood glucose <90 mg/dl

Design

Cohort

Follow-up

mean 4- to 5-year evaluation period

Authors

CNChristopher Nielson TLT.J. Lange

Discussion

Member takes

Overview

Supports graded HF risk with higher-normal glucose in nondiabetics; hypothesis-generating and requires prospective trials before practice implications.

Structured PICO

Does higher baseline blood glucose increase the incidence of heart failure in nondiabetic patients?

Population

20,810 nondiabetic patients. Excluded: prior diagnosis of diabetes, diagnosis of heart failure <1 year after initial blood glucose determinations, blood glucose determination >125 mg/dl, or use of corticosteroids, loop diuretics, insulin, or oral hypoglycemics.

Intervention

Higher baseline morning blood glucose levels (90-99 mg/dl, 100-109 mg/dl, and 110-125 mg/dl)

Comparator

Baseline morning blood glucose <90 mg/dl

Outcome

Incidence of heart failure >1 year after initial glucose determinationhard clinical

Higher baseline blood glucose levels, even within the nondiabetic range, are independently associated with a significantly increased risk of developing heart failure.

Cite This Study

Nielson et al. (2005) studied this question.

synapsesocial.com/papers/6a913c9dbd296d8bc511ff21 https://doi.org/10.2337/diacare.28.3.607

View Full Paper

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March 1, 2005Diabetes CareOpen Access

Blood Glucose and Heart Failure in Nondiabetic Patients

View Full Paper

Ask AI

Bookmark

Why the study?

Does higher baseline blood glucose increase the incidence of heart failure in nondiabetic patients?

Population

20,810 nondiabetic patients. Excluded: prior diagnosis of diabetes, diagnosis of heart failure <1 year after…

Comparison

Higher baseline morning blood glucose levels vs Baseline morning blood glucose <90 mg/dl

Design

Cohort

Follow-up

mean 4- to 5-year evaluation period

Authors

CNChristopher Nielson TLT.J. Lange

Discussion

Member takes

Overview

Supports graded HF risk with higher-normal glucose in nondiabetics; hypothesis-generating and requires prospective trials before practice implications.

Structured PICO

Does higher baseline blood glucose increase the incidence of heart failure in nondiabetic patients?

Population

Intervention

Higher baseline morning blood glucose levels (90-99 mg/dl, 100-109 mg/dl, and 110-125 mg/dl)

Comparator

Baseline morning blood glucose <90 mg/dl

Outcome

Incidence of heart failure >1 year after initial glucose determinationhard clinical

Higher baseline blood glucose levels, even within the nondiabetic range, are independently associated with a significantly increased risk of developing heart failure.

Cite This Study

Nielson et al. (2005) studied this question.

synapsesocial.com/papers/6a913c9dbd296d8bc511ff21 https://doi.org/10.2337/diacare.28.3.607

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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