Why the study?
Does higher fasting plasma glucose predict hospitalization for CHF in patients at high cardiovascular risk?
Population
31,546 high-risk subjects with ≥1 coronary, peripheral, or cerebrovascular disease or DM with end-organ…
Design
Cohort, blinded for randomized treatment
Follow-up
mean 886 days
Key result
A 1-mmol/L higher fasting plasma glucose was independently associated with an increased risk of hospitalization for congestive heart failure (HR 1.05; 95% CI 1.02-1.08; P<0.001) in high-risk patients.
Authors
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May aid HF risk stratification in high CV risk patients; leaves open whether glucose lowering prevents hospitalization.
Cohort (n=31,546)
Yes
Does higher fasting plasma glucose predict hospitalization for CHF in patients at high cardiovascular risk?
Higher fasting plasma glucose is an independent predictor of incident heart failure hospitalization in patients at high cardiovascular risk, even after adjusting for diabetes status and other risk factors.
Effect estimate: HR 1.05 (95% CI 1.02-1.08)
p-value: p=<0.001
Held et al. (2007) conducted a cohort in High cardiovascular risk without congestive heart failure (n=31,546). Fasting plasma glucose was evaluated on Hospitalization for congestive heart failure (HR 1.05, 95% CI 1.02-1.08, p=<0.001). A 1-mmol/L higher fasting plasma glucose was independently associated with an increased risk of hospitalization for congestive heart failure (HR 1.05; 95% CI 1.02-1.08; P<0.001) in high-risk patients.
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