Why the study?
Is aspirin resistance in patients with chronic coronary arterial disease predominantly caused by non-compliance?
Population
230 subjects, including 191 patients with a history of myocardial infarction (MI) and 39 normal subjects
Comparison
Observed aspirin ingestion vs Baseline (off aspirin for 7 days)
Design
Cross-sectional
Follow-up
2 hours
Authors
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Clinicians should verify adherence before diagnosing resistance; supports non-compliance predominance but leaves open prospective confirmation.
Is aspirin resistance in patients with chronic coronary arterial disease predominantly caused by non-compliance?
True pharmacological aspirin resistance is rare (approximately 3%), and the vast majority of apparent aspirin resistance in clinical practice is driven by patient non-compliance.
Schwartz et al. (2008) studied this question.
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