September 26, 2002Blood

Thrombospondin and fibrinogen bind serotonin-derivatized proteins on COAT-platelets

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Population

In vitro model of COAT-platelets (collagen and thrombin activated platelets)

Design

Preclinical

Authors

RSRóbert SzászUniversity of Debrecen GDGeorge L. DaleUniversity of Oklahoma Health Sciences Center

Discussion

Member takes

Implication

May guide antithrombotic target development; leaves open human translation from this in vitro animal model.

Structured PICO

Population

In vitro model of COAT-platelets (collagen and thrombin activated platelets)

Intervention

Photoreactive cross-linking to an albumin-(serotonin)6 conjugate and in vitro binding assays

Outcome

Identification of serotonin binding sites on COAT-plateletssurrogate

This study elucidates the mechanism of procoagulant protein retention on COAT-platelets, demonstrating that thrombospondin and fibrinogen act as serotonin binding sites.

Cite This Study

Szász et al. (2002) studied this question.

synapsesocial.com/papers/6a91485090ff22de3cb39d55 https://doi.org/10.1182/blood-2002-02-0354

View Full Paper

Ask AI

Bookmark

Thrombospondin and fibrinogen bind serotonin-derivatized proteins on COAT-platelets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Thrombospondin and fibrinogen bind serotonin-derivatized proteins on COAT-platelets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider