March 11, 2017Nucleic Acids ResearchOpen Access

Aicardi–Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion

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Population

In vitro models studying TREX1 protein and L1 retrotransposon

Comparison

TREX1 (wild-type) vs TREX1 mutants related to Aicardi-Goutières…

Design

Preclinical

Authors

PLPeng LiWuhan Polytechnic University JDJuan DuJilin University JGJohn L. GoodierJohns Hopkins University

Discussion

Member takes

Implication

May inform AGS therapeutic targets; hypothesis-generating in animals, human translation remains open.

Structured PICO

Population

In vitro models studying TREX1 protein and L1 retrotransposon

Intervention

TREX1 (wild-type)

Comparator

TREX1 mutants related to Aicardi-Goutières syndrome (AGS)

Outcome

ORF1p depletion and L1-mediated DNA damagesurrogate

TREX1 suppresses L1 retrotransposon-induced DNA damage through an exonuclease-independent mechanism involving ORF1p depletion, providing insights into autoimmune diseases like Aicardi-Goutières syndrome.

Cite This Study

Li et al. (2017) studied this question.

synapsesocial.com/papers/6a91497a80800acc7233fa58 https://doi.org/10.1093/nar/gkx178

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Aicardi–Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Aicardi–Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider