Why the study?
Does long-term treatment with ramipril alter its pharmacokinetics in elderly hypertensive patients?
Population
10 elderly patients with essential hypertension and a diastolic blood pressure between 95 and 125 mm Hg.
Design
Case_series, open
Follow-up
1 year
Authors
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Supports stable ramipril dosing without adjustment in elderly hypertensives; leaves open confirmation in larger prospective studies.
Does long-term treatment with ramipril alter its pharmacokinetics in elderly hypertensive patients?
Long-term treatment with ramipril in elderly hypertensive patients does not result in clinically relevant changes to its pharmacokinetics over 1 year.
Hosie et al. (1991) studied this question.
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