Key result
In dogs with myxomatous mitral valve disease, right ventricular function variables did not differ across disease stages or severity of pulmonary hypertension.
Why the study?
Does tissue Doppler imaging identify right ventricular functional alterations in dogs with myxomatous mitral valve disease with or without pulmonary hypertension?
Observational (n=114)
Does tissue Doppler imaging identify right ventricular functional alterations in dogs with myxomatous mitral valve disease with or without pulmonary hypertension?
In dogs with myxomatous mitral valve disease, right ventricular function variables did not differ by disease stage or pulmonary hypertension severity, though left heart echocardiographic variables correlated with pulmonary hypertension.
RV TDI variables offer limited staging utility in canine MMVD; leaves open its added value beyond left-heart parameters for PH assessment.
BACKGROUND: In human medicine, right ventricular (RV) functional parameters represent a tool for risk stratification in patients with congestive heart failure caused by left heart disease. Little is known about RV alterations in dogs with left-sided cardiac disorders. OBJECTIVES: To assess RV and left ventricular (LV) function in dogs with myxomatous mitral valve disease (MMVD) with or without pulmonary hypertension (PH). ANIMALS: One-hundred and fourteen dogs: 28 healthy controls and 86 dogs with MMVD at different stages. METHODS: Prospective observational study. Animals were classified as healthy or having MMVD at different stages of severity and according to presence or absence of PH. Twenty-eight morphological, echo-Doppler, and tissue Doppler imaging (TDI) variables were measured and comparison among groups and correlations between LV and RV parameters were studied. RESULTS: No differences were found among groups regarding RV echo-Doppler and TDI variables. Sixteen significant correlations were found between RV TDI and left heart echocardiographic variables. Dogs with PH had significantly higher transmitral E wave peak velocity and higher E/e' ratio of septal (sMV) and lateral (pMV) mitral annulus. These 2 variables were found to predict presence of PH with a sensitivity of 84 and 72%, and a specificity of 71 and 80% at cut-off values of 10 and 9.33 for sMV E/e' and pMV E/e', respectively. CONCLUSIONS AND CLINICAL IMPORTANCE: No association between variables of RV function and different MMVD stage and severity of PH could be detected. Some relationships were found between echocardiographic variables of right and left ventricular function.
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Toaldo et al. (2016) conducted an observational in Myxomatous mitral valve disease with or without pulmonary hypertension (n=114). Myxomatous mitral valve disease vs. Healthy controls was evaluated on Right ventricular echo-Doppler and tissue Doppler imaging variables. In dogs with myxomatous mitral valve disease, right ventricular function variables did not differ across disease stages or severity of pulmonary hypertension.
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