Key result
Dogs with advanced myxomatous mitral valve disease exhibited significant diastolic dysfunction compared to healthy controls, evidenced by a reduced ETDI/ATDI ratio (0.6 vs 1.6, p<0.0001).
Population
21 dogs, including 12 mature dogs with myxomatous mitral valve disease and 9 healthy adult dogs as controls.
Comparison
Echocardiographic assessment vs Healthy adult dogs
Design
Preclinical
Authors
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May support diastolic assessment in advanced canine MMVD; hypothesis-generating for human valvular cardiomyopathy research.
Cross-Sectional (n=21)
Absolute Event Rate: 0.6% vs 1.6%
p-value: p=<0.0001
Progression of myxomatous mitral valve disease in dogs is associated with significant impairment in echocardiographic indices of diastolic function.
Camacho et al. (2016) conducted a cross-sectional in Myxomatous mitral valve disease (MMVD) (n=21). Myxomatous mitral valve disease vs. Healthy dogs was evaluated on ETDI/ATDI ratio (p=<0.0001). Dogs with advanced myxomatous mitral valve disease exhibited significant diastolic dysfunction compared to healthy controls, evidenced by a reduced ETDI/ATDI ratio (0.6 vs 1.6, p<0.0001).
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